CYTOCHROME P450 ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION (ERAD): THERAPEUTIC AND PATHOPHYSIOLOGICAL IMPLICATIONS

Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications

The hepatic endoplasmic reticulum (ER)-anchored cytochromes P450 (P450s) are mixed-function oxidases engaged in the biotransformation of physiologically relevant endobiotics as well as of myriad xenobiotics of therapeutic and environmental relevance.P450 ER-content and hence function is regulated by their coordinated hemoprotein syntheses and prote

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The associations between coping resources and help-seeking intention in a sample of Chinese first-year medical students: mediation effects of coping strategies

Abstract Background Help-seeking is an adaptive coping process encompassing orientation, intention and actual behaviors.Help-seeking intention which promotes help-seeking behavior is a protective factor for mental health.However, the psychological paths for help-seeking intention in first-year medical students, a population vulnerable to mental hea

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